Msh5^tm1Htr
Targeted Allele Detail

Summary

• Symbol: Msh5^tm1Htr
• Name: mutS homolog 5; targeted mutation 1, Hein te Riele
• MGI ID: MGI:2179022
• Synonyms: Msh5-
• Gene: Msh5 Location: Chr17:35247581-35265721 bp, - strand Genetic Position: Chr17, 18.57 cM
• Alliance: Msh5^tm1Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53516
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The putative ATPase-encoding domain of this gene was replaced with a hyrgomycin resistance cassette via homologous recombination. Northern blot analysis of transcripts from homozygous mutant animals showed loss of the ATPase-enconding domain and downstream regions. (J:53516)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh5 Mutation: 49 strains or lines available

References

• Original: J:53516 de Vries SS, et al., Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. Genes Dev. 1999 Mar 1;13(5):523-31
• All: 4 reference(s)