Dmc1^tm1Tkm
Targeted Allele Detail

Summary

• Symbol: Dmc1^tm1Tkm
• Name: DNA meiotic recombinase 1; targeted mutation 1, Takashi Morita
• MGI ID: MGI:2179026
• Synonyms: Dmc1-
• Gene: Dmc1 Location: Chr15:79445698-79489310 bp, - strand Genetic Position: Chr15, 37.79 cM, cytoband E
• Alliance: Dmc1^tm1Tkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47307
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of this gene was replaced with a neomycin cassette via homologous recombination. Northern blot analysis of mutant animals detected larger RNA species due to insertion of the neo cassette. Western blot and immunohistochemistry did not detect protein in nuclear extract from testis of homozygous mutant animals. (J:47307)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmc1 Mutation: 17 strains or lines available

References

• Original: J:47307 Yoshida K, et al., The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell. 1998 Apr;1(5):707-18
• All: 2 reference(s)