Sycp3^tm1Hoog
Targeted Allele Detail

Summary

• Symbol: Sycp3^tm1Hoog
• Name: synaptonemal complex protein 3; targeted mutation 1, Christer Hoog
• MGI ID: MGI:2179041
• Synonyms: SCP3-
• Gene: Sycp3 Location: Chr10:88295449-88309098 bp, + strand Genetic Position: Chr10, 43.94 cM, cytoband C
• Alliance: Sycp3^tm1Hoog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60153
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with a neomycin cassette via homologous recombination. Gene transcripts and protein were absent in testes of adult homozygous mutant animals as assayed by Northern and Western blot, respectively. (J:60153)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sycp3 Mutation: 21 strains or lines available

References

• Original: J:60153 Yuan L, et al., The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell. 2000 Jan;5(1):73-83
• All: 28 reference(s)