Ddit3^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Ddit3^tm1Aki
• Name: DNA-damage inducible transcript 3; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2179046
• Synonyms: CHOP-, Ddit3^tm1Mori
• Gene: Ddit3 Location: Chr10:127126662-127132160 bp, + strand Genetic Position: Chr10, 74.5 cM
• Alliance: Ddit3^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76277
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 3 and 4 of this gene were replaced with a neomycin cassette via homologous recombination. (J:76277)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddit3 Mutation: 20 strains or lines available

References

• Original: J:76277 Oyadomari S, et al., Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10845-50
• All: 21 reference(s)