Oprm1^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1Jep
• Name: opioid receptor, mu 1; targeted mutation 1, John E Pintar
• MGI ID: MGI:2179052
• Synonyms: MOP-R-, MOR-1 -, MOR-1 KO
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52952
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and flanking intronic sequences were replaced with a neomycin resistance cassette. Binding assays on brain tissues of homozygous mice confirmed that no functional protein was expressed from this allele. (J:52952)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 54 strains or lines available

References

• Original: J:52952 Schuller AG, et al., Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci. 1999 Feb;2(2):151-6
• All: 29 reference(s)