Serpind1^tm1Toll
Targeted Allele Detail

Summary

• Symbol: Serpind1^tm1Toll
• Name: serine (or cysteine) peptidase inhibitor, clade D, member 1; targeted mutation 1, Douglas M Tollefsen
• MGI ID: MGI:2179102
• Synonyms: HCII-
• Gene: Serpind1 Location: Chr16:17149235-17161438 bp, + strand Genetic Position: Chr16, 10.74 cM
• Alliance: Serpind1^tm1Toll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74337
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 of this gene was replaced with a neomycin cassette via homologous recombination. Northern blot of liver from homozygous mutant animals detected a mutant transcript containing the neo sequence. Plasma from homozygous mutant animals did not contain protein product or exhibit enzyme activity. (J:74337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Serpind1 Mutation: 21 strains or lines available

References

• Original: J:74337 He L, et al., Heparin cofactor II inhibits arterial thrombosis after endothelial injury. J Clin Invest. 2002 Jan;109(2):213-9
• All: 6 reference(s)