Kcnip3^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Kcnip3^tm1Pngr
• Name: Kv channel interacting protein 3, calsenilin; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:2179103
• Synonyms: dream-
• Gene: Kcnip3 Location: Chr2:127298418-127364014 bp, - strand Genetic Position: Chr2, 62.02 cM
• Alliance: Kcnip3^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74345
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced sequences encoding EF hands I and II and the proximal 5' region of this gene (amino acids 58-143.) Northern and Western blot of brain from homozygous mutant animals verified the absence of gene expression. (J:74345)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnip3 Mutation: 26 strains or lines available

References

• Original: J:74345 Cheng HY, et al., DREAM is a critical transcriptional repressor for pain modulation. Cell. 2002 Jan 11;108(1):31-43
• All: 11 reference(s)