Nox3^het-3J
Chemically induced Allele Detail

Summary

• Symbol: Nox3^het-3J
• Name: NADPH oxidase 3; head tilt 3 Jackson
• MGI ID: MGI:2179106
• Synonyms: vst
• Gene: Nox3 Location: Chr17:3685515-3746536 bp, - strand Genetic Position: Chr17, 2.05 cM
• Alliance: Nox3^het-3J page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89010
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Chemically induced (other) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A G to A transition at the -1 position of the spice acceptor site at the intron 1 - exon 2 junction is predicted to result in the abolition of this acceptor site. As a result, PCR suggests two splice variants in the homozygous mutant: one using a cryptic acceptor site in intron 1 and then the canonical donor site of exon 2 (resulting in novel amino-acids and a premature stop codon) and one skipping exon 2 (with the coding region remaining in-frame). No complementation was seen among offspring in crosses between heterozygotes of this allele and homozygotes of head tilt or head tilt 2 Jackson. (J:89010, J:169054)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nox3 Mutation: 38 strains or lines available

References

• Original: J:76316 Monroe RJ, et al., A new allele at the head-tilt (het) locus. MGI Direct Data Submission. 2002
• All: 3 reference(s)