Adra2a^tm1Bkk
Targeted Allele Detail

Summary

• Symbol: Adra2a^tm1Bkk
• Name: adrenergic receptor, alpha 2a; targeted mutation 1, Brian K Kobilka
• MGI ID: MGI:2179108
• Synonyms: alpha2A-, alpha2A-AR^-, alpha2A-ARKO, alpha2A-KO
• Gene: Adra2a Location: Chr19:54033690-54037413 bp, + strand Genetic Position: Chr19, 49.04 cM
• Alliance: Adra2a^tm1Bkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76317
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette inserted into the gene by homologous recombination resulted in a premature stop codon within the third transmembrane domain. Confirmation of the targeting event was demonstrated through Southern analysis. (J:76317)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adra2a Mutation: 28 strains or lines available

References

• Original: J:76317 Altman JD, et al., Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Mol Pharmacol. 1999 Jul;56(1):154-61
• All: 58 reference(s)