E2f2^tm1Zubi
Targeted Allele Detail

Summary

• Symbol: E2f2^tm1Zubi
• Name: E2F transcription factor 2; targeted mutation 1, Ana Zubiaga
• MGI ID: MGI:2179111
• Synonyms: E2F2^-, E2f2^tm1Gle
• Gene: E2f2 Location: Chr4:135899705-135923368 bp, + strand Genetic Position: Chr4, 68.34 cM, cytoband D3
• Alliance: E2f2^tm1Zubi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75726
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette was inserted into exon 3. Southern and Northern analysis was utilized to confirm the targeting event and lack of transcript in homozygous mutant animals, respectively. (J:75726, J:76318)

Expression

In Mice Carrying this Mutation:	72 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying E2f2^tm1Zubi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any E2f2 Mutation: 29 strains or lines available

References

• Original: J:75726 Leone G, et al., Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105-13
• All: 45 reference(s)