Rad23b^tm1Gvh
Targeted Allele Detail

Summary

• Symbol: Rad23b^tm1Gvh
• Name: RAD23 homolog B, nucleotide excision repair protein; targeted mutation 1, Gijsbertus T J van der Horst
• MGI ID: MGI:2179121
• Synonyms: mHR23B-
• Gene: Rad23b Location: Chr4:55350043-55392237 bp, + strand Genetic Position: Chr4, 29.7 cM, cytoband B3
• Alliance: Rad23b^tm1Gvh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74288
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin cassette via homologous recombination resulting in a frameshift and the deletion of amino acids 148-228. Gene expression could not be detected in Northern and Western blot of mouse embryonic fibroblasts from homozygous mutant E13.5 embyros. (J:74288)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad23b Mutation: 42 strains or lines available

References

• Original: J:74288 Ng JM, et al., Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol Cell Biol. 2002 Feb;22(4):1233-45
• All: 5 reference(s)