Lama4^tm1Ktry
Targeted Allele Detail

Summary

• Symbol: Lama4^tm1Ktry
• Name: laminin, alpha 4; targeted mutation 1, Karl Tryggvason
• MGI ID: MGI:2179127
• Synonyms: Lama4-, Lama4^tm1Blp
• Gene: Lama4 Location: Chr10:38841511-38986184 bp, + strand Genetic Position: Chr10, 20.02 cM
• Alliance: Lama4^tm1Ktry page

Cardiomyocyte degeneration and fibrosis in the 40 week old Lama4^tm1Ktry/Lama4^tm1Ktry heart

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74287
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter region and exons 1 and 2 were replaced with a neomycin cassette via homologous recombination. Northern blot verified the absence of gene transcript in muscle and heart from homozygous mutant animals. Immunostaining of capillary basement membrane from homozygous mutants did not detect protein product. (J:74287)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lama4 Mutation: 114 strains or lines available

References

• Original: J:74287 Thyboll J, et al., Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. Mol Cell Biol. 2002 Feb;22(4):1194-202
• All: 30 reference(s)