Slc6a6^tm1Dhau
Targeted Allele Detail

Summary

• Symbol: Slc6a6^tm1Dhau
• Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6; targeted mutation 1, Dieter Haussinger
• MGI ID: MGI:2179132
• Synonyms: taut-
• Gene: Slc6a6 Location: Chr6:91661031-91736044 bp, + strand Genetic Position: Chr6, 40.73 cM
• Alliance: Slc6a6^tm1Dhau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74276
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 of this gene was replaced with a neomycin resistance gene via homologous recombination, resulting in a truncated protein deleted for transmembrane domains 1-2 as well as a large portion of the extracellular region. Transcripts including exon 1 were not expressed in kidney and liver of homozygous mutant animals as assayed by Northern blot. (J:74276)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a6 Mutation: 320 strains or lines available

References

• Original: J:74276 Heller-Stilb B, et al., Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J. 2002 Feb;16(2):231-3
• All: 14 reference(s)