Chrna6^tm1Nchx
Targeted Allele Detail

Summary

• Symbol: Chrna6^tm1Nchx
• Name: cholinergic receptor, nicotinic, alpha polypeptide 6; targeted mutation 1, Nicolas Champtiaux
• MGI ID: MGI:2179133
• Synonyms: alpha6-
• Gene: Chrna6 Location: Chr8:27893240-27903972 bp, - strand Genetic Position: Chr8, 16.02 cM, cytoband A3
• Alliance: Chrna6^tm1Nchx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74587
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4 kb region of this gene including exons 1 and 2 was replaced with a neomycin cassette via homologous recombination, resulting in the deletion of sequences encoding the translation initiation codon, signal peptide, and part of the N-terminal extracellular domain. In situ hybridization did not detect mRNA in retinal ganglion cells from brain of homozygous mutant animals. (J:74587)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna6 Mutation: 30 strains or lines available

References

• Original: J:74587 Champtiaux N, et al., Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci. 2002 Feb 15;22(4):1208-17
• All: 10 reference(s)