Col18a1^tm1Hms
Targeted Allele Detail

Summary

• Symbol: Col18a1^tm1Hms
• Name: collagen, type XVIII, alpha 1; targeted mutation 1, Harvard Medical School
• MGI ID: MGI:2179134
• Synonyms: Col18a1-
• Gene: Col18a1 Location: Chr10:76888013-77002351 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband B5-C1
• Alliance: Col18a1^tm1Hms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75861
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK/neo cassette replaces exons 17-38 of the endogenous locus. The insertion disrupts all variant forms from the locus. (J:75861)

Disease models

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Col18a1^tm1Hms

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Col18a1 Mutation: 139 strains or lines available

References

• Original: J:75861 Fukai N, et al., Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J. 2002 Apr 2;21(7):1535-44
• All: 33 reference(s)