Erbb2^tm1Mul
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm1Mul
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, William Muller
• MGI ID: MGI:2179176
• Synonyms: erbB-2^KD
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm1Mul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74283
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was targeted with a PGK-neo cassette preceded by a point mutation at lysine 757 (K757M) destroying the kinase activity of the gene product. Homozygous mutant embyros were identified by genotype analysis at E11.5-E13.5. (J:74283)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:74283 Chan R, et al., The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development. Mol Cell Biol. 2002 Feb;22(4):1073-8
• All: 2 reference(s)