Tbx1^tm1Pa
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm1Pa
• Name: T-box 1; targeted mutation 1, Virginia Papaioannou
• MGI ID: MGI:2179190
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm1Pa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70730
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A loxP-flanked neomycin selection cassette replaced most of the coding region of the gene. (J:70730)

Disease models

Expression

In Mice Carrying this Mutation:	224 assay results
In Structures Affected by this Mutation:	46 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:70730 Jerome LA, et al., DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet. 2001 Mar;27(3):286-91
• All: 39 reference(s)