Tbx1^tm1Bem
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm1Bem
• Name: T-box 1; targeted mutation 1, Bernice E Morrow
• MGI ID: MGI:2179191
• Synonyms: Tbx1-, Tbx1^tm1Rak
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm1Bem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67796
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A genomic fragment containing exons 1 and 2 was replaced with a hygromycin resistance cassette. (J:67796)

Disease models

Expression

In Mice Carrying this Mutation:	66 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:67796 Merscher S, et al., TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001 Feb 23;104(4):619-29
• All: 17 reference(s)