Tff3^tm1Dkpy
Targeted Allele Detail

Summary

• Symbol: Tff3^tm1Dkpy
• Name: trefoil factor 3, intestinal; targeted mutation 1, Daniel K Podolsky
• MGI ID: MGI:2179219
• Synonyms: Itf-
• Gene: Tff3 Location: Chr17:31344280-31348585 bp, - strand Genetic Position: Chr17, 15.8 cM
• Alliance: Tff3^tm1Dkpy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35882
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 of this gene was replaced with a neo cassette via homologous recombination resulting in the deletion of the trefoil domain. Absence of gene expression in the gastrointestinal tract of homozygous mutant animals was confirmed by Northern blot analysis and immunohistochemistry. (J:35882)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tff3 Mutation: 9 strains or lines available

References

• Original: J:35882 Mashimo H, et al., Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor [see comments]. Science. 1996 Oct 11;274(5285):262-5
• All: 15 reference(s)