Tff1^tm1Mrio
Targeted Allele Detail

Summary

• Symbol: Tff1^tm1Mrio
• Name: trefoil factor 1; targeted mutation 1, Marie-Christine Rio
• MGI ID: MGI:2179220
• Synonyms: mpS2-, TFF1^-
• Gene: Tff1 Location: Chr17:31380369-31384034 bp, - strand Genetic Position: Chr17, 15.8 cM
• Alliance: Tff1^tm1Mrio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35923
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 of this gene was disrupted by the insertion of a neo cassette via homologous recombination. Northern blot analysis detected mutant transcript from the stomachs of homozygous mutant animals. Western blot of gastric cytosol and immunohistochemistry of stomach from homozygous mutant animals did not detect protein product. (J:35923)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tff1 Mutation: 16 strains or lines available

References

• Original: J:35923 Lefebvre O, et al., Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein [see comments]. Science. 1996 Oct 11;274(5285):259-62
• All: 22 reference(s)