Runx3^tm1Yito
Targeted Allele Detail

Summary

• Symbol: Runx3^tm1Yito
• Name: runt related transcription factor 3; targeted mutation 1, Yoshiyaki Ito
• MGI ID: MGI:2179229
• Synonyms: Kyoto-Runx3^LacZ, Runx3-
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^tm1Yito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75869
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 of this gene was replaced with a LacZneo cassette via homologous recombination. The targeted allele was verified via Southern blot analysis. (J:75869)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Runx3^tm1Yito

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 27 strains or lines available

References

• Original: J:75869 Li QL, et al., Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer. Cell. 2002 Apr 5;109(1):113-24
• All: 30 reference(s)