Lifespan2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Lifespan2^DBA/2J
• Name: life span 2; DBA/2J
• MGI ID: MGI:2179255
• QTL: Lifespan2 Location: Chr10:66848222-66848397 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 34.83 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased life span in male animals compared to BALB/cJ, C3H/HeJ, and C57BL/6J. (J:73687)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Lifespan1 and Lifespan2 appear epistatic-80% of male animals exhibiting the greatest longevity inherited both the C3H/HeJ allele at Lifespan1 and the DBA/2J allele at Lifespan2.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73687

Genome scan at an average marker resolution of 23 cM was performed on an outcross population of 253 (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 animals to identify loci associated with long life span. Animals from the first 20% of deaths were excluded from the data set to maximize identification of longevity loci. Lifespan1 mapped to 48 cM on mouse Chromosome 9 with p<0.01 at D9Mit110. C3H/HeJ-derived alleles confer long life in male animals at this locus. Lifespan2 mapped to 35 cM on mouse Chromosome 10 with p<0.05 at D10Mit15. DBA/2J-derived alleles confer long life in males at Lifespan2. Lifespan3 mapped to 52 cM on mouse Chromosome 12 in linkage to long life in both males and females with p<0.01 at D12Mit167. The C57BL/6J + C3H/HeJ heterozygous genotype confers increased life span at this locus. Lifespan1 and Lifespan2 appear epistatic-80% of male animals exhibiting the greatest longevity inherited both the C3H/HeJ allele at Lifespan1 and the DBA/2J allele at Lifespan2. Two suggestive loci with additive interactions mapped to D16Mit182 and D2Mit58. BALB/cJ-derived alleles at D16Mit182 and C3H/HeJ-derived alleles at D2Mit58 additively confer longer life in female animals.

References

• Original: J:73687 Jackson AU, et al., Mouse loci associated with life span exhibit sex-specific and epistatic effects. J Gerontol A Biol Sci Med Sci. 2002 Jan;57(1):B9-B15
• All: 2 reference(s)