Naq1^RR
QTL Variant Detail

Summary

• QTL variant: Naq1^RR
• Name: nurturing ability QTL 1; RR
• MGI ID: MGI:2179260
• QTL: Naq1 Location: unknown Genetic Position: Chr5, cM position of peak correlated region/allele: 65.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: RR

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers decreased nuturing ability (as measured by decreased litter weight) compared to KK. (J:74503)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:74503

Genome scan at an average marker spacing of 21.3 cM was performed on 147 (RR x KK)F2 dams to identify loci associated with nuturing ability. Litter weight was used as an indirect measure of nurturing ability. KK females exhibit normal nurturing ability with a pup weaning rate of 97% while RR females exhibit decreased nurturing ability with a 69.9% weaning rate. A locus on mouse Chromosome 5, Naq1, mapping from 70 cM - 78 cM showed significant linkage to litter weight at 12 days after birth (LOD=4.5) and suggestive linkage at 21 days after birth (LOD=4.0). RR-derived alleles confer decreased litter weight and litter size in a recessive manner at Naq1. Potential candidate genes mapping near Naq1 include Zp3, Zan, and Adam1a. A suggestive locus mapped to 9 cM on mouse Chromosome 9 with LOD=3.2 at D9Mit90 for litter weight at day 21. RR-derived alleles confer decreased litter weight in a dominant fashion at this locus.

J:93200

Previously identified QTL Naq1 (nurturing ability QTL1) was further refined and characterized in this study. 84 microsatellite markers were typed in 159 dams from a (KK x RR)F2 intercross. KK females exhibit normal nurturing ability with a pup weaning rate of 97% while RR females exhibit decreased nurturing ability with a 69.9% weaning rate.

Naq1 originally mapped to 70 cM on mouse Chromosome 5 near D5Mit161. In this study peak linkage was observed at 72 cM on mouse Chromosome 5 near D5Mit218. Naq1 reaches LOD=5.5 for litter weight gain between 7 and 12 days of age, LOD=5.4 for litter weight at 12 days of age, and LOD=4.5 for litter weight at 21 days of age. The 95% confidence interval of Naq1 spans approximately 68 cM - 80 cM. Naq1 explains 15.8% of the phenotypic variance. The RR-derived allele confers decreased litter weight with a recessive mode of inheritance. Potential candidate genes identified in the Naq1 interval are Phkg1 (72 cM), Mmp17 (72.5 cM), Cyln2 (74 cM), Wbscr1 (74 cM), Asl (74 cM), Por (75 cM), Cldn3 (75 cM), Fzd9 (75 cM), Cldn4 (75 cM), Gtf2i (75 cM), Gnb2 (76 cM), and Hspb1 (76 cM).

A previously identified suggestive locus at 9 cM on mouse Chromosome 9 near D9Mit90 was also detected with suggestive linkage in this study. This locusreaches LOD=2.9 for litter weight gain between 7 and 12 days of age. RR-derived alleles confer decreased litter weight with a dominant mode of inheritance.

References

• Original: J:74503 Suto J, et al., Genetic analysis of inferior nurturing ability in RR mice. Reproduction. 2002 Jan;123(1):52-8
• All: 2 reference(s)