Ptgfr^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Ptgfr^tm1Sna
• Name: prostaglandin F receptor; targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2179271
• Synonyms: FP, FP^-, PGF2alpha, Ptgfr^tm1Aic
• Gene: Ptgfr Location: Chr3:151504247-151543165 bp, - strand Genetic Position: Chr3, 76.96 cM
• Alliance: Ptgfr^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42113
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZneo cassette via homologous recombination. X-gal staining was observed in ovaries of homozygous mutant animals and absence of gene expression in was verified via Northern blot analysis and radioligand binding assay. (J:42113)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptgfr^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptgfr Mutation: 24 strains or lines available

References

• Original: J:42113 Sugimoto Y, et al., Failure of parturition in mice lacking the prostaglandin F receptor. Science. 1997 Aug 1;277(5326):681-3
• All: 25 reference(s)