Tnfsf9^tm1Thw
Targeted Allele Detail

Summary

• Symbol: Tnfsf9^tm1Thw
• Name: tumor necrosis factor (ligand) superfamily, member 9; targeted mutation 1, Tania H Watts
• MGI ID: MGI:2179297
• Synonyms: 4-1BBL-, 41BBL KO, CD137L^-
• Gene: Tnfsf9 Location: Chr17:57412325-57414757 bp, + strand Genetic Position: Chr17, 29.67 cM
• Alliance: Tnfsf9^tm1Thw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76373
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette at nucleotide 52 via homologous recombination. Activated lymph node cells from homozygous mutant animals did not contain protein product as assayed by flow cytometry. (J:76373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf9 Mutation: 21 strains or lines available

References

• Original: J:76373 DeBenedette MA, et al., Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol. 1999 Nov 1;163(9):4833-41
• All: 23 reference(s)