Smyd1^tm1Dsr
Targeted Allele Detail

Summary

• Symbol: Smyd1^tm1Dsr
• Name: SET and MYND domain containing 1; targeted mutation 1, Deepak Srivastava
• MGI ID: MGI:2179298
• Synonyms: Bop-
• Gene: Smyd1 Location: Chr6:71190924-71239265 bp, - strand Genetic Position: Chr6, 32.14 cM
• Alliance: Smyd1^tm1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76212
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, which encompass the MYND domain, are replaced with a neo-resistance gene. RT-PCR failed to detect transcript in hearts from homozygous mutant embryos at E9.5 (J:76212)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smyd1 Mutation: 45 strains or lines available

References

• Original: J:76212 Gottlieb PD, et al., Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May;31(1):25-32
• All: 2 reference(s)