Olig2^tm1Rth
Targeted Allele Detail

Summary

• Symbol: Olig2^tm1Rth
• Name: oligodendrocyte transcription factor 2; targeted mutation 1, David H Rowitch
• MGI ID: MGI:2179312
• Synonyms: Olig2-
• Gene: Olig2 Location: Chr16:91022345-91025565 bp, + strand Genetic Position: Chr16, 52.6 cM
• Alliance: Olig2^tm1Rth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75868
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region for this gene was replaced with a neomycin cassette via homologous recombination. In situ hybridization of spinal chord from homozygous mutant embryos did not detect gene transcript. (J:75868)

Expression

In Mice Carrying this Mutation:

100 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Olig2 Mutation: 46 strains or lines available

References

• Original: J:75868 Lu QR, et al., Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 5;109(1):75-86
• All: 14 reference(s)