Onecut1^tm1Flem
Targeted Allele Detail

Summary

• Symbol: Onecut1^tm1Flem
• Name: one cut domain, family member 1; targeted mutation 1, Frederic P Lemaigre
• MGI ID: MGI:2179340
• Synonyms: Hnf6-
• Gene: Onecut1 Location: Chr9:74769203-74796930 bp, + strand Genetic Position: Chr9, 41.93 cM
• Alliance: Onecut1^tm1Flem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62595
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The proximal promoter region and exon 1 were replaced with a neomycin cassette via homologous recombination. Absence of gene expression in pancreas of homozygous mutant animals was verified by RT-PCR. (J:62595)

Expression

In Mice Carrying this Mutation:	289 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Onecut1 Mutation: 12 strains or lines available

References

• Original: J:62595 Jacquemin P, et al., Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000 Jun;20(12):4445-54
• All: 28 reference(s)