Cyp19a1^tm1Toda
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^tm1Toda
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Katsumi Toda
• MGI ID: MGI:2179439
• Synonyms: Ar-, ArKO
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^tm1Toda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79603
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 87 nucleotides of exon 9 were replaced with a neomycin resistance gene via homologous recombination. Northern blot of gene transcripts from ovaries of homozygous mutant animals verified the absence of exon 9 and enzyme assay detected negligible levels of enzyme activity. (J:70359)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 39 strains or lines available

References

• Original: J:79603 Nemoto Y, et al., Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice. J Clin Invest. 2000 Jun;105(12):1819-25
• All: 23 reference(s)