Sox17^tm1Ysk
Targeted Allele Detail

Summary

• Symbol: Sox17^tm1Ysk
• Name: SRY (sex determining region Y)-box 17; targeted mutation 1, Yoshiakira Kanai
• MGI ID: MGI:2179440
• Synonyms: Sox17-
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^tm1Ysk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75946
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a PGK-neo cassette by homologous recombination. Western blot of E7.5 homozygous mutant embryos verified absence of encoded protein. (J:75946)

Disease models

Expression

In Mice Carrying this Mutation:	177 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

References

• Original: J:75946 Kanai-Azuma M, et al., Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002 May;129(10):2367-79
• All: 13 reference(s)