Gata4^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Gata4^tm1Eno
• Name: GATA binding protein 4; targeted mutation 1, Eric N Olson
• MGI ID: MGI:2179443
• Synonyms: GATA4-
• Gene: Gata4 Location: Chr14:63436371-63509141 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Gata4^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40145
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons containing the 2 DNA-binding zinc finger domains were replaced with a neomycin cassette via homologous recombination. RT-PCR analysis of homozygous mutant embryos did not detect wild-type transcript. (J:40145)

Expression

In Mice Carrying this Mutation:	59 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata4 Mutation: 36 strains or lines available

References

• Original: J:40145 Molkentin JD, et al., Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997 APR 15;11(8):1061-1072
• All: 18 reference(s)