Daxx^tm1Led
Targeted Allele Detail

Summary

• Symbol: Daxx^tm1Led
• Name: Fas death domain-associated protein; targeted mutation 1, Philip Leder
• MGI ID: MGI:2179457
• Gene: Daxx Location: Chr17:34128388-34134564 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Daxx^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56796
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 2.5 kb genomic fragment containing exon 1 and part of exon 2. (J:56796)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Daxx Mutation: 34 strains or lines available

References

• Original: J:56796 Michaelson JS, et al., Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev. 1999 Aug 1;13(15):1918-23
• All: 4 reference(s)