Slit1^tm1.1Matl
Targeted Allele Detail

Summary

• Symbol: Slit1^tm1.1Matl
• Name: slit guidance ligand 1; targeted mutation 1.1, Marc Tessier-Lavigne
• MGI ID: MGI:2179459
• Synonyms: Slit1-
• Gene: Slit1 Location: Chr19:41588696-41732104 bp, - strand Genetic Position: Chr19, 34.99 cM
• Alliance: Slit1^tm1.1Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73904
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed neo cassette was excised from Slit1^tm1Matl via in vivo cre mediated recombination, leaving the endogenous locus disrupted by a cassette containing an endoplasmic reticulum KDEL retention sequence, a stop codon, and an IRES-tauGFP fusion protein. The initial insertion of the cassette replaced sequence encoding a portion of the second leucine rich repeat. In situ hybridization studies using a 3' antisense probe did not detect mRNA in the ventral spinal cord of homozygous mutant E11.5 embryos. (J:73904)

Expression

In Mice Carrying this Mutation:

205 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slit1 Mutation: 70 strains or lines available

References

• Original: J:73904 Plump AS, et al., Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron. 2002 Jan 17;33(2):219-32
• All: 55 reference(s)