Slit2^tm1Matl
Targeted Allele Detail

Summary

• Symbol: Slit2^tm1Matl
• Name: slit guidance ligand 2; targeted mutation 1, Marc Tessier-Lavigne
• MGI ID: MGI:2179460
• Synonyms: Slit2-
• Gene: Slit2 Location: Chr5:48140480-48465075 bp, + strand Genetic Position: Chr5, 26.05 cM
• Alliance: Slit2^tm1Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73904
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a floxed PGK-neomycin resistance cassette preceded by an inframe stop codon, an IRES element, and sequences encoding a tauGFP fusion protein, deleted part of two 5' exons including the putative signal sequence (SS) and sequences encoding part of the first leucine rich repeat. (J:73904)

Expression

In Mice Carrying this Mutation:	98 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slit2 Mutation: 88 strains or lines available

References

• Original: J:73904 Plump AS, et al., Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron. 2002 Jan 17;33(2):219-32
• All: 63 reference(s)