Traf2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Traf2^tm1Mak
• Name: TNF receptor-associated factor 2; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2179513
• Synonyms: TRAF2^-
• Gene: Traf2 Location: Chr2:25407994-25436952 bp, - strand Genetic Position: Chr2, 17.32 cM
• Alliance: Traf2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44360
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the two exons encoding the ring finger domain. Immunoprecipitation and western blot analysis on lysates derived from homozygous mice confirmed that no detecable protein was expressed. (J:44360)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Traf2 Mutation: 25 strains or lines available

References

• Original: J:44360 Yeh WC, et al., Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity. 1997 Nov;7(5):715-25
• All: 17 reference(s)