Cfc1^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Cfc1^tm1Mms
• Name: cryptic, EGF-CFC family member 1; targeted mutation 1, Michael M Shen
• MGI ID: MGI:2179530
• Synonyms: Cryptic
• Gene: Cfc1 Location: Chr1:34574729-34583392 bp, + strand Genetic Position: Chr1, 13.34 cM, cytoband B
• Alliance: Cfc1^tm1Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58104
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 3 and all of exons 4 and 5 were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant E7.5 embryos were identified by PCR analysis. (J:58104)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cfc1 Mutation: 22 strains or lines available

References

• Original: J:58104 Yan YT, et al., Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 1999 Oct 1;13(19):2527-37
• All: 9 reference(s)