Lefty1^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Lefty1^tm1Hmd
• Name: left right determination factor 1; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:2179534
• Synonyms: lefty-1-, Lefty1^null
• Gene: Lefty1 Location: Chr1:180762587-180765965 bp, + strand Genetic Position: Chr1, 84.46 cM, cytoband F
• Alliance: Lefty1^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49052
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All 4 exons of this gene were replaced with a neo cassette via homologous recombination. Homozygous mutant animals were identified via Southern blot analysis. (J:49052)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lefty1 Mutation: 41 strains or lines available

References

• Original: J:49052 Meno C, et al., lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 1998 Aug 7;94(3):287-97
• All: 11 reference(s)