Ccr6^tm1(EGFP)Irw
Targeted Allele Detail

Summary

• Symbol: Ccr6^tm1(EGFP)Irw
• Name: C-C motif chemokine receptor 6; targeted mutation 1, Ifor R Williams
• MGI ID: MGI:2179543
• Synonyms: CCR6-, CCR6-GFP
• Gene: Ccr6 Location: Chr17:8454875-8475973 bp, + strand Genetic Position: Chr17, 4.9 cM, cytoband A1
• Alliance: Ccr6^tm1(EGFP)Irw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73935
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A self-excising cre-neomycin resistance cassette replaced 213 bp of coding sequence at the 5' end of the gene, and placed the open reading frame of EGFP, followed by the late SV40 polyadenylation signal, inframe with upstream sequences. The B cell lineage expression pattern from this allele visualized using EGFP matches that of wild-type gene expression previously described using a mouse-specific monoclonal antibody. (J:73935)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr6 Mutation: 37 strains or lines available

References

• Original: J:73935 Kucharzik T, et al., CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse. Eur J Immunol. 2002 Jan;32(1):104-12
• All: 21 reference(s)