Relb^{Tg(H2-K1/GH1)106Bri}
Transgenic Allele Detail

Summary

• Symbol: Relb^{Tg(H2-K1/GH1)106Bri}
• Name: avian reticuloendotheliosis viral (v-rel) oncogene related B; transgene insertion 106, Ralph L Brinster
• MGI ID: MGI:2179544
• Synonyms: 272H, line 272-4, relb^-, Relb^Tg106Bri, Relb^{Tg(H2K/GH1)106Bri}, Tg(H-2K + GH1), Tg(H-2K +GH1)Bri106, Tg(H2KhGH1)106Bri
• Gene: Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
• Alliance: Relb^{Tg(H2-K1/GH1)106Bri} page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: The mutation was generated by microinjection of a construct containing a 7.8 kb fragment that includes the complete mouse H2-K structural locus and 2 kb of 5' flanking sequence, as well as a nonfunctional 2.1 kb portion of the human growth hormone gene (hGH1), which serves as a marker gene. The random insertion of this transgene just downstream of the exon encoding the Rel domain disrupted the gene. RT-PCR analysis of RNA derived from slpeen and thymus of homozygous mice demonstrated that no detectable transcript was expressed from this allele. Immunohistochemistry experiments on sections of thymus and spleen of homozygous mice confirmed that no detectable encoded protein was present. (J:23081)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Relb^Tg(H2-K1/GH1)106Bri/Relb^Tg(H2-K1/GH1)106Bri	C57BL/6-Relb^Tg(H2-K1/GH1)106Bri
hm2	Relb^Tg(H2-K1/GH1)106Bri/Relb^Tg(H2-K1/GH1)106Bri	involves: C57BL/6
ht3	Relb^Tg(H2-K1/GH1)106Bri/Relb^+	involves: C57BL/6
cx4	Map3k14^aly/Map3k14^+ Relb^Tg(H2-K1/GH1)106Bri/Relb^+	involves: C57BL/6 * C57BL/6J

Phenotypes:

Affected Systems	hm1	hm2	ht3	cx4
show or hide all annotated terms
cellular	√
decreased T cell proliferation	√
endocrine/exocrine glands	√
absent thymus medulla	√
growth/size/body	√
decreased body size	√
cachexia	√
enlarged spleen	√
hematopoietic system	√	√	√	√
decreased T cell proliferation	√
absent thymus medulla	√
enlarged spleen	√
increased granulocyte number	√
decreased B cell number	√
decreased pre-B cell number	√
decreased T cell number	√
decreased NK T cell number		√	√	√
increased macrophage cell number	√
homeostasis/metabolism	√	√		√
decreased circulating interferon-gamma level				√
decreased circulating interleukin-4 level		√
skin edema	√
immune system	√	√	√	√
decreased T cell proliferation	√
absent thymus medulla	√
enlarged spleen	√
increased granulocyte number	√
decreased B cell number	√
decreased pre-B cell number	√
decreased T cell number	√
decreased NK T cell number		√	√	√
increased macrophage cell number	√
decreased circulating interferon-gamma level				√
decreased circulating interleukin-4 level		√
abnormal Peyer's patch morphology	√
decreased Peyer's patch number			√	√
small Peyer's patches			√	√
absent Peyer's patches		√
abnormal lymph node morphology	√
absent lymph nodes		√
abnormal antigen presentation	√
increased inflammatory response	√	√
liver inflammation	√
glomerulonephritis	√
lung inflammation	√
skin inflammation	√
integument	√
skin edema	√
skin inflammation	√
ruffled hair	√
hyperkeratosis	√
liver/biliary system	√
liver inflammation	√
liver fibrosis	√
pale liver	√
mortality/aging	√
premature death	√
preweaning lethality, incomplete penetrance	√
renal/urinary system	√
glomerulonephritis	√
respiratory system	√
lung inflammation	√
abnormal lung morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Relb Mutation: 33 strains or lines available

References

• Original: J:76450 Lo D, et al., A recessive defect in lymphocyte or granulocyte function caused by an integrated transgene. Am J Pathol. 1992 Nov;141(5):1237-46
• All: 30 reference(s)