Relb^tm1Brv
Targeted Allele Detail

Summary

• Symbol: Relb^tm1Brv
• Name: avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:2179545
• Synonyms: Relb-, RelB^KO
• Gene: Relb Location: Chr7:19340142-19363352 bp, - strand Genetic Position: Chr7, 9.93 cM
• Alliance: Relb^tm1Brv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22675
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a 0.5 kb fragment containing most of exon 4, which encodes the beginning of the Rel homology domain. Western blot analysis on lysates derived from homozygous mice confirmed that no detectable protein was present. (J:22675)

Disease models

Expression

In Structures Affected by this Mutation:

25 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Relb Mutation: 33 strains or lines available

References

• Original: J:22675 Weih F, et al., Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell. 1995 Jan 27;80(2):331-40
• All: 45 reference(s)