Acvr2a^tm1Hsch
Targeted Allele Detail

Summary

• Symbol: Acvr2a^tm1Hsch
• Name: activin receptor IIA; targeted mutation 1,Heinrich Schrewe
• MGI ID: MGI:2179547
• Synonyms: AcrRIIA-, Acvr2a^tm1Enl, IIA-, IIA-KO
• Gene: Acvr2a Location: Chr2:48704121-48793276 bp, + strand Genetic Position: Chr2, 28.38 cM
• Alliance: Acvr2a^tm1Hsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57262
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The kinase domain of this gene was disrupted by replacing 135 bp of exon 9 and 1.3 kb of intron 9 with a neo cassette by homologous recombination. Homozygous mutant animals were identified by Southern blot analysis. (J:57262)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr2a Mutation: 40 strains or lines available

References

• Original: J:57262 Song J, et al., The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol. 1999 Sep 1;213(1):157-69
• All: 10 reference(s)