Fgf18^tm1Sjt
Targeted Allele Detail

Summary

• Symbol: Fgf18^tm1Sjt
• Name: fibroblast growth factor 18; targeted mutation 1, Shinji Takada
• MGI ID: MGI:2179607
• Synonyms: Fgf18-
• Gene: Fgf18 Location: Chr11:33067430-33097400 bp, - strand Genetic Position: Chr11, 19.21 cM
• Alliance: Fgf18^tm1Sjt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75880
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by insertion of a lacZneo cassette via homologous recombination. Homozygous mutant embryos at E9.5-E18.5 were identified by PCR analysis. (J:75880)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf18 Mutation: 10 strains or lines available

References

• Original: J:75880 Ohbayashi N, et al., FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev. 2002 Apr 1;16(7):870-9
• All: 4 reference(s)