Ccr6^tm1Gma
Targeted Allele Detail

Summary

• Symbol: Ccr6^tm1Gma
• Name: C-C motif chemokine receptor 6; targeted mutation 1, Gabriel Marquez
• MGI ID: MGI:2179613
• Synonyms: CCR6-
• Gene: Ccr6 Location: Chr17:8454875-8475973 bp, + strand Genetic Position: Chr17, 4.9 cM, cytoband A1
• Alliance: Ccr6^tm1Gma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68191
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced most of the coding exon, leaving the sequences that encode the 25 carboxy terminal amino acids. Northern analysis of spleen and thymus did not detect mRNA in homozygous mutant mice. (J:68191)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ccr6 Mutation: 37 strains or lines available

References

• Original: J:68191 Varona R, et al., CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J Clin Invest. 2001 Mar;107(6):R37-45
• All: 16 reference(s)