Vgf^tm1Srjs
Targeted Allele Detail

Summary

• Symbol: Vgf^tm1Srjs
• Name: VGF nerve growth factor inducible; targeted mutation 1, Stephan R J Salton
• MGI ID: MGI:2179681
• Synonyms: Vgf^-
• Gene: Vgf Location: Chr5:137055246-137062205 bp, + strand Genetic Position: Chr5, 76.13 cM
• Alliance: Vgf^tm1Srjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56499
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire Vgf coding sequence was replaced with the PGK-driven neomycin cassette. The absence of transcript and protein as a result of the targetting event was demonstrated through Northern and Western analysis, respectively. (J:56499)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vgf Mutation: 26 strains or lines available

References

• Original: J:56499 Hahm S, et al., Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron. 1999 Jul;23(3):537-48
• All: 6 reference(s)