Nfkb2^tm1Brv
Targeted Allele Detail

Summary

• Symbol: Nfkb2^tm1Brv
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:2179689
• Synonyms: p100-
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^tm1Brv page

Stomach abnormalities in Nfkb2^tm1Brv/Nfkb2^tm1Brv mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43469
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The carboxy terminal domain of the protein was disrupted by insertion of a termination codon at position 451 and the replacement of the sequences encoding residues 451 to 690 with a neomycin resistance cassette. Immunoprecipitation analysis on lysates of stimulated thymocytes demonstrated that the larger precursor protein was not made, but a processed and truncated p52 protein was present. (J:43469)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:43469 Ishikawa H, et al., Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med. 1997 Oct 6;186(7):999-1014
• All: 14 reference(s)