Nfkb2^tm1Sbn
Targeted Allele Detail

Summary

• Symbol: Nfkb2^tm1Sbn
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Ulrich Siebenlist
• MGI ID: MGI:2179705
• Synonyms: NF-kappaB/p52 null, Nfkb2-, p52/p100-
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^tm1Sbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45437
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences encoding the dimerization/DNA binding domain, the nuclear translocation sequence and the first seven ankyrin domains. Western blot analysis on lysates derived from spleen of homozygous mice confirmed that no detectable isoform of the encoded protein was present. (J:45437)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:45437 Franzoso G, et al., Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med. 1998 Jan 19;187(2):147-59
• All: 34 reference(s)