Tnfsf10^tm1Mjs
Targeted Allele Detail

Summary

• Symbol: Tnfsf10^tm1Mjs
• Name: tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Mark J Smyth
• MGI ID: MGI:2179709
• Synonyms: Tnfsf10^-, TRAIL-
• Gene: Tnfsf10 Location: Chr3:27371226-27393814 bp, + strand Genetic Position: Chr3, 10.82 cM, cytoband A3
• Alliance: Tnfsf10^tm1Mjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73948
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences between nucleotides 274 and 371. Flow cytometry experiments on liver mononucleocytes and natural killer cells confirmed that no detectable protein was present on the cell surface. (J:73948)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnfsf10^tm1Mjs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf10 Mutation: 24 strains or lines available

References

• Original: J:73948 Cretney E, et al., Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol. 2002 Feb 1;168(3):1356-61
• All: 43 reference(s)