Prkcd^tm1Kin
Targeted Allele Detail

Summary

• Symbol: Prkcd^tm1Kin
• Name: protein kinase C, delta; targeted mutation 1, Kei-ichi Nakayama
• MGI ID: MGI:2179710
• Synonyms: nPKDdelta^-, PCK-delta-, PKCdelta^-
• Gene: Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
• Alliance: Prkcd^tm1Kin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76135
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance gene via homologous recombination. Protein product was absent in brain of homozygous mutant animals as determined by Western blot analysis. (J:76135)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcd Mutation: 54 strains or lines available

References

• Original: J:76135 Miyamoto A, et al., Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature. 2002 Apr 25;416(6883):865-9
• All: 42 reference(s)