Tnfrsf11b^tm1Eac
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11b^tm1Eac
• Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); targeted mutation 1, Edward A Clark
• MGI ID: MGI:2179712
• Synonyms: opg -
• Gene: Tnfrsf11b Location: Chr15:54114014-54141700 bp, - strand Genetic Position: Chr15, 21.15 cM
• Alliance: Tnfrsf11b^tm1Eac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67105
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a genomic fragment containing sequences encoding part of the signal peptide, the first two cysteine rich repeats and part of the third cysteine rich repeat. Northern blot analysis on total RNA derived from liver of homozygous mice demonstrated that a smaller transcript was expressed from this allele, but it is predicted to produce a nonfucntional protein. (J:67105)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf11b Mutation: 31 strains or lines available

References

• Original: J:67105 Yun TJ, et al., Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. J Immunol. 2001 Feb 1;166(3):1482-91
• All: 16 reference(s)