Rph3a^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Rph3a^tm1Sud
• Name: rabphilin 3A; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2179730
• Synonyms: rabphilin KO
• Gene: Rph3a Location: Chr5:121078562-121148155 bp, - strand Genetic Position: Chr5, 61.17 cM
• Alliance: Rph3a^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56293
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced two exons encoding residues 74-146 of the encoded protein. Western blot analysis on brain tissues of homozygous mice confirmed that no encoded protein was detected. (J:56293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rph3a Mutation: 43 strains or lines available

References

• Original: J:56293 Schluter OM, et al., Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. J Neurosci. 1999 Jul 15;19(14):5834-46
• All: 6 reference(s)